NBS-nytt
11.06.2019
The Nature paper in 2017 on autophagy's role in cancer from the Institute for Cancer Research in Oslo generated considerable interest in Norway and internationally. The Institute's Annual Report said, Among research highlights, the...group on tumour-host biology, headed by Tor Erik Rusten, published a particularly remarkable finding in 2017.'
In addition to the team at Oslo, researchers at UiT and in Hungary and the USA were coauthors of this study (1). The experimental system used (2) was originally developed in the USA, involving transgenic Drosophila larvae expressing green fluorescent protein (GFP) in Rasactivated eye-precursor cells. To monitor for autophagy expression, this paper also used a gene for a red fluorescent marker (mCherry) coupled to an autophagy-specific (Atg8) promoter. Taken together, these transgenic technologies represent a clever way of simultaneously monitoring tumor progression, metastasis and autophagy expression in transparent living larvae of Drosophila (Fig
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